Analytical

DS 8000 (with Piston Pump) SMART

Tablet Dissolution Test Apparatus (6+2)

The new LABINDIA Dissolution Apparatus DS 8000 provide great versatility and configurability. It fulfils all requirements relating to ASTM & FDA Mechanical Calibration. The state-of-the-art Dissolution Testing with touch screen is elegant in design and user friendly with advanced features. The DS 8000 is precision engineered for USP<711> dissolution for ease of use. Allows storage of up to 200 product test run parameters.

Diagnostic functionality and validation report of the system is reliable enough for QC applications and flexible for R&D use.

 

FEATURES:

  • Advanced, Micro-Controller based:

User-friendly, complies with current USP, IP & BP specifications

  • Moulded water bath with 6+2 (3+1 & 3+1) vessel configuration enables comparative studies
  • Mono shaft design with easy changeover between Apparatus I & II eliminates routine height validation as per USP
  • Paddles, Baskets and Vessels are laser marked with serial numbers for traceability
  • Automated Tablet dispenser - drops 6 dosage form at single instance
  • Low Evaporation Lids:

» The conical shape low evaporation recovery lids reduces media loss during long run

» Integrated pre-centered lids; no manual removal or positioning of lids. This ensures automatic vessel centering and precise positioning of paddle/basket with shaft without any special tool as per pharmacopeia requirements

  • State-of-the-art design:

            » Easy placement and locking of vessels, the Ease-align system allows the vessels to simply slide into the place (Bionet                        Locking) Once placed, vessels do not float even when empty

            » Facility to monitor Vessel temp., with an external Digital Temperature Sensor

 

 

REGULATORY COMPLIANCE

  • DS 8000 Smar t meets all requirements relating to validation, qualification and calibration
  • Appropriate qualification documents (I.Q. / O .Q.) can be supplied with the instrument

PUMP SYSTEM - PP 08

 

  • Piston Pump - PP 08 is Microprocessor controlled and is ideal for sample withdrawal from 6, 7, 8 channels
  • The Piston Pump - PP 08 with iner t ceramic rotor overcomes all absorption issues
  • High flow rates of 25 ml / min can be achieved with accuracy better than ±5%
  • Rinse function for reducing car ryover issues
  • Surfactant Media Compatibility

 

 

 

SAMPLE COLLECTION

 

  • 18 X 8 sets of samples can be collected. F or more sampling interval, 24 X 8 collection trays are available
  • Option of 1.5ml & 2ml HPLC vial 24 X 8 tray is available
  • Auto recognition Sensor for tray with alar m facility fo collection of sample
  • Wide mouth vial to minimise SLS spillover problem due to foaming characteristics
  • Easy positioning with respect to vials or test tube tray for easy changeover

 

 

 

INTELLIGENT SAMPLING SYSTEM

  • Automated sampling as per USP Specifications. Sampling tubes are lowered in the media only at the time of sampling and withdrawn immediately after sampling, thus no par t of the assembly contributes motion, agitation or vibration.
  • Sampling tubes are accurately moved to the USP sampling position i.e. a zone mid way between the sur face of media and the top of paddle/basket parameters, not less than 1 cm from the vessels wall as selected in the method
  • 6 vessels temperature monitoring system automatically measures and records the temperature of individual vessel at specified sample points

 

 

ADDITIONAL FEATURES

  • Built-in Validation software
  • Facility to RINSE the entire sampling path in between sampling timepoint to eliminate contamination & car ryover
  • Specially developed cleaning system to clean the entire sampling path after each run
  • Facilities to per form the dissolution test using 3 buffers (Buffer changing) to cater the application of enteric coating tablets
  • Recovery Test facility to study 100% Dr ug Dissolution
  • Split & on-time interval

 

SPECIFICATIONS:

Control                                                           Micro Controller

Method Storage                                            Minimum 1000 methods with parameters

Software Compliance                                   21 CFR Part 11

Temperature Range                                      20°C to 55°C

Temperature Accuracy                                up to 45°C ±0.1°C & >45°C up to 55°C ±0.2°C

Temperature Resolution                              0.1°C

Temperature Sensor                                    DTS - Digital Temperature Sensor

Evaporation Loss                                         1% (at 50 RPM / 37􀁎C / 1000mL / 24hrs)

Display                                                           7’’ high resolution display with capacitive touch screen

Paddle/Basket Shaft Stirring Speed           20 to 350 RPM (20 to 250±1, 251 to 350±2)

Sampling Time Selectivity                            Fixed / programmable (Varying Intervals)

Time Interval Selectivity                               In steps of 1 Minute

Vessel Capacity                                             1000 mL

Water Bath                                                     17 litres capacity with built-in water level sensor / front loaded drain tap for easy draining of the water                                                                              bath

Maximum Number Of Intervals                   50

Dissolution Process Time                               1 min to 1200 hrs

Print Interface                                                USB / WiFi Direct enabled Printer

Data Backup Interface                                  USB / LAN Port

Electrical Power                                            110/220V AC - 50 Hz/60 Hz

Dimension (W*D*H)                                      71.5*60*70.5 cm

Weight                                                              80 kg Approx.

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