Tablet Dissolution Test Apparatus DS 8000 with Peristaltic Pump


Dissolution Tests are conducted to determine the drug release patterns, physiological availability and bioavailability of for mulated drug products. It is also used as a quality control tool.

The Dissolution rate of a drug from the solid state is defined as the amount of drug substance that goes into solution per unit time under standardised conditions of liquid / solid inter face, temperature, and solvent composition.

LABINDIA brings to you the State-of-the-art Dissolution Testing Apparatus in elegant design with advanced features, which supports USP 1, 2, 5 & 6. Apparatus for Intrinsic test &  stationary basket methods are available.



  Advanced, Micro-Controller based: User-friendly, complies with current USP, IP & EP specifications.

• Splash waterproof keyboard: Alphanumeric polyester soft keys for Keyboard.

• Moulded water bath with 6+2 (3+1 & 3+1) vessel configuration enables comparative studies.

• External vibration free Water Circulator: for uniform water circulation, with audible, low water level alarm, with indication on display for safety.

• Mono shaft design with automatic adjustment for 25 mm depth setting with easy changeover between Apparatus I & II eliminates routine height validation as per USP.

• Paddles, Baskets and Vessels are laser marked with serial numbers for traceability.

• Tablet dispenser - drops 6 dosage form at single instance.


Low Evaporation Lids:

» The conical shape low evaporation recover y lids reduces media loss during long run.

» Integrated pre-centered lids; no manual removal or positioning of lids. This ensures automatic vessel centering and precise positioning of paddle/basket with shaft without any special tool as per pharmacopeia requirements.


 State-of-the-art design:

» Easy placement and locking of vessels, the Easealign system allows the vessels to simply slide into the place (Bionet Locking). Once placed, vessels do not float even when empty.

» Facility to monitor Vessel temp., with DTS Technology (Digital Temperature Sensor)



• DS 8000 meets all requirements relating to validation, qualification

and calibration.

• Appropriate qualification documents (I.Q. / O.Q.) can be supplied with

the instrument.



• Automated sampling as per USP Specifications. Sampling tubes are

lowered in the media only at the time of sampling and withdrawn

immediately after sampling, thus no par t of the assembly contributes

motion, agitation or vibration.

• Sampling tubes are accurately moved to the USP sampling position

i.e. a zone mid way between the sur face of media and the top of

paddle/basket parameters, not less than 1 cm from the vessels

wall as selected in the method.

• 6 vessels temperature monitoring system automatically measures

and records the temperature of individual vessel at specified

sample points.



• Imported Pump with click-n-go Cassette design provides defined and

repeatable occlusion conditions.

• Fixed length pump tubing with stopper for sampling volume accuracy.

• Volume calibration through sof tware.

• Tygon pump tubing for SLS Compatibility with long life.

• High repeatability on all Channels.

• 12 actively driven stainless steel rollers.



• 10 X 6 or 16 X 6 sets of samples can be collected. For more

sampling interval, 24 X 6 collection trays are available.

• Option of 1.5ml & 2ml HPLC vials tray is available.

• Over Head Design for electronic safety and fail safe operation.

• Sensor to locate proper position of tray with alar m facility for

collection of sample.

• Wide mouth vial to minimise SLS spillover problem due to

foaming characteristics

• Easy positioning with respect to vials or test tube tray for easy




• Facility to RINSE the entire sampling path in between sampling time

point to eliminate contamination & carryover

• Specially developed cleaning system to clean the entire sampling

path after each run.

• Facilities to perform the dissolution test using two buffers (Buffer

changing) to cater the application of enteric coating tablets.

• Recovery Test facility to study 100% Drug Dissolution.

• Split & on-time interval



• Control: Micro controller based (Advanced version of microprocessor).

• Display: 40 x 2 line back lighted liquid crystal display (LCD)

• Keyboard: Alphanumeric splash waterproof polyester sof t keys.

• Method Storage: 15 programs with parameters.

• Data Storage: Available with Non-Volatile memory.

• Water Bath: 17 litres capacity with built-in water level sensor / Front located drain tap for easy draining of the water bath.

• Bath Circulation: External vibration free water circulator

• Temperature Range: 20°C to 55°C

• Temperature Resolution: 0.1ºC

• Temperature Control Accuracy: up to 45°C ±0.1°C & >45°C up to 55°C ±0.2°C

Temperature Sensor: DTS - Digital Temperature Sensor

• Paddle/Basket Shaft Speed: Range 20 to 250 RPM ±1%

• Dissolution Vessel: option for Polycarbonate / Glass Vessels (clear, amber, peak vessels, 250, 150 & 100 ml. dissolution vessels available)

• Sampling Time Selectivity: Fixed/Programmable (varying intervals)

• Time Interval Selectivity: In steps of 1 minute

• Sampling Volume Range: 0.5 - 25.5 ml

• Replenishing mode selectivity: User selectable

• Rinsing Functionality: Optional

• Maximum Number of Intervals: 30

• Dissolution Process Time: 1 min. to 720 hours

• 6 Channel Temperature Reader: Built-In

Report Format: a ) GLP & Pharmacopeia compliant b) Program parameter repor t

Output: a) Printer: Compatible for deskjet, inject and dot matrix printer b) RS232C: For PC Connectivity

c) 21 CFR Part 11 compliance software available (Optional)

• Power: 110 / 220 V AC - 50 Hz / 60 Hz

• Environmental Operating Conditions: a) Operation: Indoor. b) Temperature: Ambient to 45ºC. c) Humidity: 5 to 90% non-condensing.

• Dimensions: 71.5 x 60 x 70.5 cms. (W x D x H)

• Weight: 80 kgs. approx. (Basic Dissolution System)

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